Genomic Informatics

informatics_shawnThe largest Unit of the CGC, principal investigators in this group study diverse areas of computational biology and bioinformatics including: prediction of gene structure and function based upon analysis of DNA sequence and charge distribution – including prediction of genomic structure, regions of gene-gene interaction, and promoter or regulatory regions; data mining including the prediction of protein coding regions and regulatory sequences; gene expression analysis including the use of support vector machine learning algorithms for supervised learning and prediction of presumptive regulatory sites by statistical analysis; integration of software for genomic applications; comparative genomics and evolutionary biology including the construction of phylogenetic trees to predict structural and functional relationships among genes; use of mutation rates and conserved sequence DNA to predict coding seqments and functional motifs; prediction of gene pathways and networks; and mathematical approaches to pathway prediction.