The high throughput genotyping group consists of three ABI model 377 DNA sequencers and high throughput robotics. The group has a capacity of approximately 1.25 million microsatellite marker genotypes per year. Recent projects include whole genome scans for autism, celiac disease, bipolar disorder, and several skin disorders.
The molecular genetics laboratories investigate a host of Mendelian and complex human disorders. Several current studies focus on various forms of epilepsy, including both Mendelian and complex etiologies. The study of complex genetic traits ranges from the analysis of large numbers of extended bipolar disorder pedigrees, to the study of affected sib pairs with celiac disease or autism, to behavioral genetic studies of working memory and fear conditioning as potential endophenotypes to guide the study of human anxiety disorders and schizophrenia, respectively.
Statistical and population genetic studies range from genetic epidemiological study of heart disease and breast cancer to genetic modeling of disease parameters for complex traits to the comparative analysis of allelic variation and environment in populations of Korean ancestry throughout the world. The Division includes a major focus on the development of new statistical tools for the analysis of complex traits and on the evaluation of current statistical programs.
The major focus of this group is the development of strategies and methods to map and identify complex trait alleles. This Division and others at the CGC collaborate with Columbia University scientists to study the genetic basis of diabetes in mice and humans. Another focus of this Division is the development of computational and bioinformatic approaches to predict the effect of single nucleotide polymorphisms on resulting protein structure or function.